子宫内膜癌组织中促凋亡线粒体蛋白BNIP3的表达及意义

摘要

目的 探讨促凋亡线粒体蛋白(BNIP3)在子宫内膜癌变过程中的表达及意义.方法 采用荧光定量PCR和免疫组化的方法测定BNIP3在52例子宫内膜癌组织、14例子宫内膜不典型增生组织及36例正常子宫内膜组织的表达情况.结果 BNIP3 mRAN及蛋白水平在子宫内膜不典型增生组的表达高于对照组与子宫内膜癌组,且三组差异均有统计学意义(P＜0.05).BNIP3 mRNA及蛋白的表达水平与子宫内膜癌的临床病理特征无显著相关性(P＞0.05).结论 子宫内膜癌组织中BNIP3表达增高.检测BNIP3的表达情况可能有助于子宫内膜恶性变的早期诊断及预后的判断.%Objective To investigate the expression and clinical significance of Bcl-2 adenocarcinoma E1B 19 kD interacting protein 3 (BNIP3) in the process of endometrial malignant change.Methods The expression of BNIP3 in 52 samples of endometrial carcinoma tissues,14 samples of atypical hyperplasia of endometrial tissues and 36 normal endometrial tissues was detected by FQ-PCR and immunohistochemistry.Results The expression of BNIP3 mRNA and protein in atypical hyperplasia of endometrial tissues was higher than those in normal endometrial tissues and endometrial carcinoma tissues,and there was statistically significant differences between each two groups (P ＜ 0.05).This study did not reveal any significant association between BNIP3 expression and clinicopathologic parameters of endometrial carcinoma patients (P ＞ 0.05).Conclusions The expression of BNIP3 in endometrial carcinoma tissue was increased.The detection of BNIP3 expression might be useful for early diagnosis and prognosis of endometrial carcinoma.