子宫内膜癌组织中过氧化物酶体增生物激活受体γ的表达及意义

摘要

目的 观察子宫内膜癌组织中过氧化物酶体增生物激活受体γ(PPARγ)的表达,并分析其意义.方法 采用免疫组化技术检测40份子宫内膜癌组织及其癌旁组织、30份正常子宫内膜组织中PPARγ的表达情况,分析其与子宫内膜癌患者临床病理特征的关系.结果 PPARγ在子宫内膜癌中的阳性表达率为67.50％,显著高于正常子宫内膜(13.33％)及癌旁组织(17.50％)(P均＜0.01).子宫内膜癌组织中PPARγ阳性表达与肿瘤组织学分级、FIGO分期有关(P均＜0.05).结论 子宫内膜癌组织中PPARγ过表达；检测其表达可能对子宫内膜癌的诊断有一定价值.%Objective To investigate the expression rate and clinical significance of peroxisome proliferators-activated receptor gamma(PPARγ) in endometrial carcinoma.Methods Immunohistochemical SP method was used to detect the expression of PPARγin 30 normal endometrium,40 endometrial carcinoma tissues and the corresponding paracarcinoma tissues.The relationship between the pathological characteristics and the expression was analyzed.Results The positive expression rate of PPARγ (67.50％)in the endometrial carcinoma tissues was significantly higher than those in normal endometrium and the corresponding paracarcinoma tissues (13.33％ and 17.50％,respectively) (P ＜0.01).The positive expression rate of PPARγ in endometrial carcinoma tissues was related with histological grading and FIGO staging (P ＜ 0.05).Conclusion Overexpression of PPARγis an early event,and detecting the expression has some value in the diagnosis of endometrial carcinoma..