目的：观察不同程度心房颤动（房颤）患者红细胞分布宽度（ RWD）、血浆高敏C反应蛋白（ hs-CRP）水平、左心房直径的变化，并探讨其与房颤程度的关系。方法房颤患者（房颤组）111例，其中阵发性房颤20例，持续性房颤40例，永久性房颤51例。选取年龄、性别、基础疾病与房颤组相匹配且无房颤病史的患者109例为对照组。采用全自动血细胞分析仪检测RWD，ELISA法检测血浆hs-CRP，超声心动图检查测量左心房直径。结果房颤组RDW、血浆hs-CRP水平、左心房直径分别为12．80％±0．91％、（2．50±0．62）ng／L、（37．92±6．38）mm；对照组分别为12．22％±0．26％、（1．07±0．58）ng／L、（33．65±4．70）mm；两组三项指标相比，P均＜0．05。不同程度房颤患者随病情严重程度增加，RDW、血浆hs-CRP水平及左心房直径逐渐增高，阵发性、持续性、永久性房颤患者两两相比，P均＜0．05。结论房颤患者RDW、血浆hs-CRP水平升高，左心房直径扩大，并与房颤的严重程度有关。%Objective To observe the changes of red blood cell distribution width ( RDW) , high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter in patients with varying degrees of atrial fibrillation (AF), and to investigate their relationship with disease severity.Methods Our study enrolled 111 patients with AF ( AF group) , including 20 ca-ses of paroxysmal AF, 40 cases of persistent AF and 51 cases of permanent AF.Another 109 subjects without AF history were selected as controls ( control group) who matched for sex, age and atherosclerotic risk factors.RWD was detected by automatic blood cell analyzer, ELISA was used to detect the plasma hs-CRP, and echocardiography was used to measure the left atrium diameter.Results The levels of RDW, hs-CRP and left atrial diameter in the AF and control groups were 12.80%±0.91%, (2.50 ±0.62) ng/L, (37.92 ±6.38)mm and 12.22%±0.26%, (1.07 ±0.58) ng/L, (33.65 ± 4.70) mm, respectively;and statistical difference was found (all P<0.05).Furthermore, RDW, hs-CRP and left atrial diameter were increased with the severity of AF types in subgroup analysis (all P<0.05).Conclusion The levels of RDW, hs-CRP and left atrial diameter of AF patients increase, which is related with the AF severity.
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