血清hs-CRP及VEGF水平对急性心肌梗死经皮冠状动脉介入治疗术后心血管事件的影响

摘要

目的 探讨血清高敏C反应蛋白(hs-CRP)及血管内皮生长因子(VEGF)对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后主要心血管不良事件(MACE)的影响.方法 选择AMI行PCI术后患者116例,根据术后是否发生MACE随机分为MACE组20例,非MACE(NMACE)组96例,分析术前,术后1 h、24 h及7 d血清hs-CRP及VEGF水平.结果 术后1 h、24 h、7 d,MACE组血清hs-CRP分别为(5.79±1.13)、(6.87±1.42)、(3.51±0.89)mg/L,VEGF分别为(167.8±49.8)、(146.8±43.9)、(121.5±29.6)pg/mL;NMACE组血清hs-CRP分别为(4.57±1.09)、(5.38±1.21)、(2.67±0.58)mg/L,VEGF分别为(145.7±40.3)、(115.6±39.7)、(95.7±21.7)pg/mL,两组不同时间点血清hs-CRP、VEGF比较差异均有统计学意义(P均<0.05).结论 血清hs-CRP及VEGF水平对预测AMI患者PCI术后MACE具有一定的临床价值.%Objective To explore effects of serum high-sensitivity C-reactive protein ( hs-CRP) and vascular endo-thelial growth factor (VEGF) on the major adverse cardiovascular events (MACE) in patients with acute myocardial infarc-tion (AMI) after percutaneous coronary intervention (PCI).Methods Totally 116 patients with AMI were treated by PCI.According to the occurrence of MACE after PCI , the patients were divided into the MACE group of 20 cases and non-MACE (NMACE) group of 96 cases.We analyzed the levels of hs-CRP and VEGF in patients before PCI , and at 1 h, 24 h, and 7 d after PCI.Results At 1 h, 24 h, and 7 d after PCI, the serum hs-CRP levels were (5.79 ±1.13), (6.87 ± 1.42), and (3.51 ±0.89) mg/L in the MACE group, and the serum VEGF levels were (167.8 ±49.8), (146.8 ± 43.9), and (121.5 ±29.6) pg/mL, respectively;the serum levels of hs-CRP in the NMACE group were (4.57 ±1.09), (5.38 ±1.21), and (2.67 ±0.58) mg/L, and the serum hs-CRP levels were (145.7 ±40.3), (115.6 ±39.7), and (95.7 ±21.7) pg/mL, respectively.Significant differences were found at different time points between these two groups (all P<0.05).Conclusion The serum hs-CRP and VEGF levels have some clinical value in predicting the occurrence of MACE in patients with AMI after PCI .