目的：探讨重性抑郁症患者经氟西汀治疗6周后生存质量的改善情况及其影响因素。方法：收集重性抑郁症患者及正常对照各100例，病例组统一口服氟西汀20～40 m g／d治疗，用药时间为6周，治疗前后进行HAMD-17、SF-36、TESS等相关量表的评估；正常对照组仅进行量表评定。结果：病例组治疗前后其生存质量显著低于正常对照组，治疗6周后病例组生存质量明显改善，SF-36各因子分显著增高，HAMD减分率与生活质量的改善情况呈正相关，同时药物不良反应对生活质量也有一定的影响，有不良反应患者PF和V T因子分显著低于无不良反应患者。结论：重性抑郁症患者生存质量显著下降，即使有效治疗6周后仍不能使其生活质量恢复到正常人群水平。患者生存质量的改善与临床疗效呈一定正相关，同时也受药物不良反应及其他因素的影响。%Objective:To investigate the life quality improvement and infect factors of major depression patients after six weeks treatment of fluoxetine .Methods :100 major depressive patients and 100 healthy controls were selected in this study .All patients were accepted six-week therapies of fluoxetine (20~40mg/d) and assessed with HAMD ,SF-36 and TESS before and after therapy .Healthy controls were assessed with above scales .Results :Life qualities of patients were significantly lower than those in normal group either before or after treatment .Six-week treatment later ,each factor score of SF-36 has a significant difference compared with the score before therapy . There was a certain direct correlation between HAMD reductive ratio and life quality .In addition ,side reactions were also influence the life quality .The scores of PF and VT in side reactions group were lower than those in group without side reactions .Conclusion :Life quality of major depression decrease significantly .Fluoxetine can improve life quality of patients notably in six weeks ,but can not reach the normal level in short term .There is a certain posi-tive correlation between the effect of fluoxetine and improvement of life quality in patients .Meanwhile life quality is also influenced by other factors such as side reactions of drug and so on .
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