Objective:To investigate the application value of plasma t-PA,PAI-1,D-D and vWF:Ag levels af-ter replacement operation of lower limb joints with deep vein thrombus form.Methods:The serum and clinical datas of 90 patients were collected,devided into DVT groups(42cases),non- DVT group(48 cases)and symptomatic group(18 cases)on the basis whether happened DVT or emerged symptoms.The levels of plasma t-PA,PAI-1,D-D and vWF:Ag were detected by automatic blood coagulation instrument in comparative analysis of the changes on plasma t-PA,PAI-1,D-D and VWF:Ag levels in the relations with DVT.Results:Compared with plasma t-PA,PAI-1,D-D and vWF:Ag levels in the non-DVT group,t-PA levels in the DVT groups and symptomatic group signifi-cantly lowered,and PAI-1,vWF:Ag and D-D levels significantly rose,the difference had statistical significance(P<0.01);Compared with those in the DVT group,t-PA levels in the symptomatic group significantly lowered,and PAI-1,vWF:Ag and D-D levels significantly rose,the difference had statistical significance(P<0.01);The plasma t-PA and PAI 1 and vWF:Ag levels in the DVT groups and symptomatic group had a significant correlation with D-D lev-els(P<0.01).Conclusion:Detection of t-PA,PAI-1,D-D and vWF:Ag levels can predict in happaning DVT in after replacement operation of lower limb joints,and estimate the development of the disease condition.%目的:探讨血浆组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活抑制物-1(PAI-1)、D-二聚体(D-D)和血管性血友病因子抗原(vWF:Ag)水平检测在下肢关节置换术后并发下肢深静脉血栓形成中的应用价值.方法:收集行下肢关节置换术治疗的90例患者的血清及临床资料,依据是否发生下肢深静脉血栓形成(DV T)及是否出现临床症状分为DV T 组、有症状组和无DV T 组,其中DV T 组42例,无DV T组48例、有症状组18例.采用全自动血凝仪检测血浆t-PA、PAI-1、D-D和vWF:Ag水平.比较分析以上指标的变化与DV T的关系.结果:与无DV T 组比较,DV T 组和有症状组血浆t-PA水平显著降低,PAI-1、vWF:Ag和D-D水平显著增高,差异有统计学意义(P<0.01);与DV T 组比较,有症状组血浆 t-PA 水平显著降低(P<0.01),PAI-1、D-D和vWF:Ag水平显著增高,差异有统计学意义(P<0.01).DV T 组和有症状组的t-PA、PAI-1和vWF:Ag水平与D-D水平具有显著相关性(P<0.01).结论:检测血浆t-PA、PAI-1、D-D和vWF:Ag水平可预测下肢关节置换术后DV T 的发生,估计病情的发展状况.
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