A series of pyrazolo [3,4-b] pyridines have been synthesized through the reaction of pyrazol-5-amine , arylglyoxals and malononitrile in acetic acid at 100℃under microwave irradiation .This method has the ad-vantages of short reaction times ( 20 ~30 min ) , excellent selectivity , simple operation as well as environmental friendly.The structures of products were characterized by IR , 1HNMR, 13CNMR and HRMS.Furthermore, the product 6-amino-4-(4-chlorobenzoyl)-1,3-dimethyl-1H-pyrazolo [3,4-b] pyridine-5-carbonitrile 4a was confirmed by X-ray diffraction analysis .%以氨基吡唑、芳酮醛水合物和丙二腈为原料,醋酸为溶剂,在100℃微波辐射下高效制备一系列吡唑并[3,4-b]吡啶衍生物.此制备方式具有反应快(反应时间为20~30 min)、操作简单、选择性高和环境友好等优点.产物的结构可通过高分辨质谱、红外光谱、核磁共振氢谱和碳谱进行表征;其中化合物6-氨基-4-(4-氯苯甲酰基)-1,3-二甲基-1H-吡唑[3,4-b]吡啶-5-腈4a的结构经由X射线单晶衍射进一步确认.
展开▼