全氟萘烷液体在前房中的长期临床观察

摘要

Objective　To observe the effects of residual perfluorocarbon liquid(PFCL) droplets in the anterior chamber in patients after vitreoretinal(VR) surgery for complicated retinal detachments.Methods　The study group consisted of nine patients(nine eyes)aged 16～64 in whom droplets of perfluorodeclin liquid(PFDL) appeared in the anterior chamber subsequent to VR surgery for complicated retinal detachments involving scleral bucking, vitrectomy and/or lensectomy, the peeling of pre-retinal membrane, perfluorodecalin injection, and perfluorodeclin liquid-silicone oil or fluid-air exchange. Mean follow-up was 10.3 months.Results　Three to 30 droplets of perfluorodeclin liquid were found in the anterior chambers in 9 eyes. There was no corneal complication or inflammatory reactions or blood vessel invasion into the corneal stroma or increased intraocular pressure.Conclusion　Residual perfluorodeclin liquid droplets in the anterior chamber are well tolerated and do not induce corneal damage or ocular inflammation.%目的观察玻璃体视网膜手术中应用过氟化碳液体后在前房中残留的小滴长期影响。方法观察组有9例(9只眼)，均为复杂性视网膜脱离玻璃体视网膜手术后，在前房内残留全氟萘烷液体的患者。手术方法为玻璃体切除联合巩膜扣带技术，包括三通道睫状体平部晶状体/玻璃体切除、膜剥离、全氟萘烷液体使用、眼内激光、硅油-全氟萘烷液体交换或气体-全氟萘烷液体交换。平均随访10.3mo。结果 9例患者术后前房中发现全氟萘烷液体3～30滴(平均14滴)，追踪期内所有的患者角膜透明，未见角膜基质肿胀和增厚、内皮损害、后弹力层皱折及血管侵入角膜基质层，未见明显的炎症反应及眼压增高。结论全氟萘烷液体小滴在前房内长期残留，无明显毒性反应，不会引起明显眼部损害及眼部感染。