肾上腺髓质素家系分子的心血管效应及病理生理意义

摘要

Adrenomedullin family includes adrenomedullin (ADM),intermedin (IMD) and different peptide fragments derived from prepro-ADM or prepro-IMD.Recent researches found the interaction between different prepro-peptides or different peptide fragments,which plays a crucial role in maintaining homeostasis of cardiovascular system as well as participates in the occurrence and development of cardiovascular disease.This review intends to introduce cardiovascular effects and pathophysiological significance of adrenomedullin family peptides from function level,receptor level and signaling pathway.%肾上腺髓质素家系包括肾上腺髓质素(adrenomedullin,ADM)、肾上腺髓质素2(或称中介素,intermedin,IMD)及两者前体原分子的不同剪切片段.近年研究发现,肾上腺髓质素家系前体分子或活性分子内部不同片段间存在相互作用,共同参与心血管系统稳态的调控,在心血管系统疾病的发生发展中发挥着重要的作用.本文拟从肾上腺髓质素家系不同剪切片段的功能多样性、受体的多选择性及受体后信号通路对肾上腺髓质素家系的心血管效应及病理生理意义进行简要综述.