Correlation of bisphenol A action on genes interfering with estrogen signaling pathways and the development of endometriosis

摘要

Bisphenol A(BPA),as an environmental endocrine disruptor,affects human health by interfering with hormone secretion in the body.Endometriosis(EMs)is an estrogendependent disease that is influenced by a variety of factors such as genetics,oxidative stress,immunity,and environment for its onset.In recent years,special attention has been paid to the influence of genetic polymorphisms on the pathogenesis of EMs.A search of the Comparative Toxicology Database revealed that BPA can act on a variety of different genes to induce disease development by regulating gene expression and that some genes play equally important roles in the development of EMs.Among them,we selected four genes(EGFR,ESR2,FOS,KRAS)in the estrogen signaling pathway,and now we review the mechanism of BPA acting on these four genes in different ways and the role of these four genes in the development of EMs,which will provide a reference for the subsequent study of the mechanism of BPA involvement in the development of EMs.