金核壳结构复合纳米颗粒在生物医学中的应用

摘要

Au nanocomposites,as a new core-shell structure,have the advantage of both the core and shell structure,which endows them with excellent optical,electrical and catalytic properties as well as with good compatibility.Au nanocomposites are,therefore,widely used in the fields of biology,medicine and chemistry.Basing on literature analysis,the present article mainly reviewed the application of the core-shell Au in biology and medicine,including the detection of protein,DNA,bacterial and virus,as well as tumor hyperthermia,bioimaging,biosensor,drug delivery and release.And an outlook was also provided in this review to improve the preparation technology for better clinical application.%核壳结构纳米材料是一种新型复合材料.贵金属金纳米核壳材料同时具有核和壳的性质,以及独特的光学、电学、催化性能和良好的生物相容性,因此在生物、化学、医学等领域具有巨大的应用价值.基于文献分析,综述了金及其核壳结构纳米复合颗粒在生物及医学上的应用,包括蛋白质、DNA、细菌和病毒的检测,以及肿瘤热疗、生物成像、生物传感、药物传递与释放等.并对完善制备技术以便更好地应用于临床进行了展望.