Objective To explore the clinical effect and safety of ziprasidone combined with risperidone on first episode schizophrenia. Methods 128 cases with first episode schizophrenia were randomly divided into 2 groups. Control group( n = 62 )received risperidone, experience group( n = 66 )was given ziprasidone. Clinical effect, PANSS scores and incidence of adverse reactions of the two groups were compared. Results The effective rates of experience group and control group were 97. 0% and 95. 2% respectively( P > 0. 05 ) ;Negative scores of experience group at 4 and 8 weeks after treatment were much lower than those of control group( P 0.05);治疗后4周、8周齐拉西酮组阴性症状评分显著低于利培酮组(P<0.05);利培酮组泌乳/月经异常、静坐不能及体重增加的发生率显著高于齐拉西酮组(P<0.05).结论 齐拉西酮与利培酮治疗首发精神分裂症患者疗效相当,但齐拉西酮可显著改善阴性症状,不良反应较少.
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