Objective To compare the curative effect of venlafaxine and flupentixol and melitracen tablets on anxiety and depressive disorder of the troops. Methods 67 soldiers from troop stationed in Hengyang were investigated through Hamilton anxiety scale( HAMA )and Hamilton depression scale( HAMD ). Patients were randomly divided into two groups,patients in venlafaxine group( groups A,n =35 )were given venlafaxine,patients in flupentixol and melitracen tablets group( group B, n=32 ) were given flupentixol and melitracen tablets. After 2 weeks, 3 months and 6 months,the HAMA,HAMD and effective rate were recorded. Results After 2 weeks,3 months and 6 months,the HAMA and HAMD decreased in the two groups( P < 0. 05 ), and there were significant difference between the two groups at 6 months after treatment P <0. 05 ). The common adverse effect in group A was nausea,dizziness,constipation,etc, and they were disappeared after 2 weeks. No significant adverse effect was found in group B. The effective rate of group A was higher than that of group B at 6 months after treatment( P < 0. 05 ). Conclusion Venlafaxine and flupentixol and melitracen tablets are effective for anxiety and depressive disorder of the troops in early stage,long-term follow-up shows that venlafaxine is more effective than flupentixol and melitracen tablets.%目的 观察文拉法辛及黛力新治疗部队官兵焦虑抑郁障碍的效果.方法 收集2008年1月至2012年6月因消化道症状为主在我院消化科住院的部队患者,经排除器质性疾病并采用汉密尔顿焦虑抑郁量表评分,明确诊断为焦虑抑郁障碍者67例,随机分为文拉法辛组(35例)及黛力新组(32例),治疗后2周、3个月、6个月观察患者初始症状,记录焦虑抑郁量表评分.结果 治疗2周、3个月、6个月时,两组焦虑抑郁量表评分均降低(P<0.05);治疗6个月时,文拉法辛组低于黛力新组(P<0.05).文拉法辛组常见的不良反应为恶心、头昏、便秘等,2周后基本消失;黛力新组无明显不良反应.治疗6个月时文拉法辛组有效率高于黛力新组(P<0.05).结论 文拉法辛及黛力新治疗部队焦虑抑郁障碍患者均有明显效果,早期差异无统计学意义,但长期随访结果显示,文拉法辛效果更稳定,其疗效优于黛力新.
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