Objective To discuss the clinical value of hydrochloric acid penehyclidine( penehyclidine ) treatment for septic shock. Methods 80 patients admitted to our hospital from February 2010 to December 2011 were randomly divided into 4 groups,20 cases in each group. Group A ( control group )was given conventional treatment,on the basis of conventional treatment, B, C,D groups were given intravenous injection of different concentrations of penehyclidine. The clinical efficacy of the 4 groups were observed. Results 69 cases were successfully rescued, 11 died,and the overall curative rate was 86. 25% . 17 cases of group A,group B,group D were successfully rescued,3 died respectively. 18 cases of group C were were rescued,2 died. The curative rates of the four groups was 85% ,85% ,90% and 85% respectively( P > 0. 05 ). After intravenous low-dose( 2 mg )penehyclidine, the patients' heart rate, MAP, bowel sounds were improved more significantly compared with control group( P 0.05).静脉注射低剂量(2 mg)长托宁后,患者的心率、MAP、肠鸣音等与对照组比较差异有统计学意义(P<0.05).B组SpO2、血乳酸、末梢转暖时间、末梢转暖持续时间与A组比较差异有统计学意义,C、D组末梢转暖时间、末梢转暖持续时间与A组比较差异有统计学意义(P<0.05).结论 盐酸戊乙奎醚抢救脓毒性休克疗效显著,值得临床推广.
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