艾普拉唑、阿莫西林、左氧氟沙星三联法治疗幽门螺杆菌感染的临床观察

摘要

Objective To discuss the efficacy and safety of triple therapy of ilaprazole, amoxicillin and levofloxacin on Helicobacter pylori( Hp ) eradication. Methods 91 patients with Hp infection suffering from peptic ulcer were randomized to treatment group and control group. The treatment group were administered ilaprazole( 5 mg, twice daily ) + amoxicillin( 1 000 mg, twice daily ) + levofloxacin( 200 mg, twice daily )for a week. The control group were administered ilaprazole( 5 mg, twice daily ) + amoxicillin( 1 000 mg, twice daily ) + metronidazole( 400 mg, twice daily )for a week. All patients were treated with ilaprazole( 5 mg,once daily )for another 3 weeks. The Hp eradication, symptoms, peptic ulcer healing and side-effects were observed after 4 weeks. Results The Hp eradication rate of treatment group and control group were 91. 3 % and 73. 3 % respectively(P 0. 05 ),89. 1 % vs. 84. 4 % ( P > 0. 05 ), 19. 7 % vs. 17. 8 % ( P > 0. 05 ), respectively. Conclusion The triple therapy of ilaprazole, amoxicillin and levofloxacin( 1 week )is ideal for Hp eradication.%目的 探讨艾普拉唑+阿莫西林+左氧氟沙星1周疗法根除幽门螺杆菌(HP)的疗效及安全性.方法 选择91例HP阳性消化性溃疡患者,随机分为2组.治疗组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+左氧氟沙星(200 mg,2次/d)联合治疗.对照组采用艾普拉唑(5 mg,2次/d)+阿莫西林(1 000 mg,2次/d)+甲硝唑(400 mg,2次/d)联合治疗.两组治疗7 d后继续用艾普拉唑5 mg,1次/d,共3周.疗程结束4周后复查胃镜和HP,观察HP根除率、症状缓解率、溃疡愈合率和不良反应.结果 治疗组和对照组的HP根除率分别为91.3 %、73.3 %(P0.05).结论 艾普拉唑+阿莫西林+左氧氟沙星三联 1周疗法是根除HP的理想方案.