苏顺注射液联合爱全乐氧气雾化吸入对降低腹部术后肺部感染的临床研究

摘要

目的 探讨苏顺注射液联合爱全乐氧气雾化吸入对预防腹部术后肺部感染的临床疗效. 方法 2013年12月至2014年12月在我科行开腹手术的患者80例,随机分为2组,对照组42例,试验组38例. 对照组:庆大霉素4万U+0. 9%生理盐水4 mL;试验组:爱全乐8 mL+苏顺1 mg;疗程:两组均给药1周,2次/d. 治疗前后分别比较各组PaO2、PaCO2 及肺部感染的情况. 结果 治疗前,对照组与试验组患者的PaO2 [ ( 76. 3±6.98)、(76.70±6.6) mmHg]和PaCO2[(35.47±6.34)、(36.4±8.30) mmHg]比较差异均无统计学意义(P>0. 05);治疗后,对照组与试验组患者的 PaO2 [(78. 30±3. 23 )、(81. 30±4. 34) mmHg]和 PaCO2 [(39. 51±9. 32)、(32. 40±8. 31) mmHg]比较差异有统计学意义,试验组患者PaO2 高于对照组(P<0. 05),PaCO2 低于对照组(P<0. 05). 试验组咳嗽、咳痰、呼吸困难及术后肺部并发症发生率、有效率均高于对照组(P<0. 05). 结论 苏顺注射液联合爱全乐雾化吸入对于术后预防肺部并发症有效率高,治疗效果更为明显.%Objective To observe the effect of terbutaline sulfate injection combined with ipratropium bromide solution for inhalation on postoperative pulmonary infection. Methods Eighty cases in our hospital from December 2013 to December 2014 after abdominal surgical operation were randomly divided into treatment group and control group,42 cases in control group were given gentamicin 40 000 U+nomal saline 4 mL;38 cases in treatment group were given terbutaline sulfate 1 mL injection and ipratropium bromide solution 8 mL for inhalation. All the patients were trea-ted for 1 week,twice daily. Results There was no significant difference in PaO2:(76. 3±6. 98)mmHg vs. (76. 70±6. 6) mmHg and PaCO2:(35. 47±6. 34)mmHg vs. (36. 4±8. 30) mmHg between control group and treatment group before treatment. After treatment,there were significant differences in PaO2: (78. 30±3. 23) mmHg vs. (81. 30±4. 34) mmHg and PaCO2: (39. 51±9. 32) mmHg vs. (32. 40±8. 31) mmHg between control group and treatment group. In treatment group,the incidences of cough,spitting,shortness of breath,and postoperative pulmonary complica-tions were significantly lower than those of control group ( P<0. 05 ) . Conclusion Terbutaline sulfate injection and ipratropium bromide solution for inhalation is effective in preventing postoperative pulmonary complications.