急性早幼粒细胞白血病小鼠动物模型建立的研究现状

摘要

急性早幼粒细胞白血病(Acute promyelocytic leukemia,APL)是造血组织的一类恶性疾病.动物模型是探讨人类相关疾病的重要工具.研究表明,APL小鼠模型可以通过转基因、逆转录病毒介导和白血病细胞移植的方法建立,且该三种方法建立的模型均可再移植.这些模型的建立为了解APL发病机制和疗效研究奠定了基础.判断模型是否成功建立,可以通过血常规、血涂片和骨髓涂片检查、免疫学、分子生物学及病理学的相关检查完成.成功建立APL动物模型,可为研究人类APL发生、发展和评价药物疗效提供重要的实验基础及理论依据,从而有助于人们进一步了解APL.%Acute promyelocytic leukemia(APL)is a class of malignant disease of hematopoietic tissue. Animal models are important tools for exploring human-related diseases.Many studies have beer shown that APL mouse models can be established by transgenic,retroviral-mediated and leukemia cell transplantation.These models established by these three methods can be re-transplanted.The establishment of these models lays the foundation for understanding the pathogenesis and efficacy of APL.In order to determine whether the model is successfully established,these methods can be used for blood tests,blood smear and bone marrow smear,immunol-ogy,molecular biology and pathology related to complete the examination.Successful establishment of APL animal model can provide important experimental basis and theoretical basis for the study,development and evaluation of drug efficacy in APL,which will help people to understand human APL further.