Bioactive Compound from Streptomyces sp. KB1 TISTR2504 as Effective Disinfectant against Microorganisms

摘要

A host environment cleaning using disinfectants is the most effective way to prevent the pathogen’s transmission.This study compared the activity among of commercial liquid disinfectants[3%hydrogen peroxide(HP),and 70%ethyl alcohol(EA)]and bioactive-compounds(BCs)from Streptomyces sp.KB1 on indicating microorganisms:Bacillus subtilis ATCC 6633 as representative of spores;Staphylococcus aureus TISTR 517 and clinical methicillin-resistant S.aureus as representative of gram-positive bacteria,Escherichia coli TISTR 887,Pseudomonas aeruginosa TISTR 1467,and extended spectrum beta-lactamase(ESBL)-Klebsiella pneumoniae 342 as representative of gram-negative bacteria;Candida albicans TISTR 5779 as representative of yeast.Results showed that B.subtilis spores are resistant to 70%EA and BCs from strain KB1-which are biocidal to TISTR strains and clinical isolate MRSA,ESBL-in the free floating microorganism(suspension test).On the other hand,this resistance was not observed with 3%HP.Thus,3%HP showed more promise for disinfecting microorganisms than that 70%EA and BCs.However,BCs did show the antimicrobial activities equal as 70%EA.The results might be implied that the using of BCs from selected bacterial strain as effective disinfectant against microorganism,especially vegetative cell,is a sustainable application in nearly future,to reduce using the chemical substances and zero wastes.