Design and development of optimal invasomes for transdermal drug delivery using computer program

摘要

Capsaicin(CAP)is a major pungent component that has been widely studied in medical and pharmaceutical fields.CAP was used both orally and topically for pain relief.However,the extreme pungency and the water insolubility of CAP lead to its restriction in the development of CAP as drug delivery system[1].Our previous study suggested that the computer software exhibited a beneficial role in the development of menthosomes for transdermal drug delivery[2].To confirm the reliability and reproducibility of simultaneous optimal formulations,the optimal ultraflexible liposomes(invasomes)estimated by the computer software(Design Expert?)were experimentally formulated and investigated.