Objective To investigate the relationship between the expression of Raf-1 in nasopharyngeal carcinoma (NPC) and the sensitivity to radiotherapy. Method 72 cases of NPC were included in the analysis, and were stratified as high radiosensitivity group (n=37) and low radiosensitivity group (n=35), in which the expression of Raf-1 protein was detected by immunohistochemical staining. Result There was no significant difference in gender, age, clinical stage, histological type and differentiation between the two groups (P>0.05);The positive expression rate of Raf-1 pro-tein in the high radiosensitivity group was 29.73%, which was lower than that in the low radiosensitivity group at 91.43%, and the difference was statistically significant (P< 0.05); The overall expression intensity of Raf-1 protein in the high sensitivity group was significantly lower than that in the low sensitivity group (P<0.05); The positive expres-sion of Raf-1 has sensitivity of 97.14%, and specificity of 70.27%in predicting the radiation resistance in NPC patients, with the positive predictive value being 75.56%, and negative predictive value being 96.29%. Conclusion The positive expression rate and expression intensity of Raf-1 protein are related to the radiation resistance of nasopharyngeal carcino-ma, which is useful in predicting the curative effect of radiotherapy for nasopharyngeal carcinoma.%目的 探讨鼻咽癌组织Raf-1的表达与鼻咽癌放疗敏感性的关系.方法 选取72例鼻咽癌患者,根据患者放疗疗效分为放疗敏感患者37例(放疗敏感组),放疗抵抗患者(放疗抵抗组)35例,采用免疫组化染色检测两组Raf-1蛋白表达情况.结果 两组患者性别、年龄、临床分期、组织分型及分化类型比较差异无统计学意义(P>0.05);放射敏感组Raf-1蛋白阳性表达率为29.73%,低于放射抵抗组的91.43%(P<0.05);放射敏感组Raf-1蛋白表达总体强度明显弱于放射抵抗组(P<0.05);Raf-1蛋白阳性表达预测鼻咽癌患者放疗抵抗的灵敏度为97.14%,特异度为70.27%,阳性预测值为75.56%,阴性预测值为96.29%.结论 Raf-1蛋白阳性表达率和表达强度与鼻咽癌放疗抵抗有关,对预测鼻咽癌放疗疗效有一定价值.
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