survivin与c-MYC在胃癌组织中的表达及意义

摘要

Objective To explore the expression and significance of survivin and c-MYC in gastric cancer. Method The expression of survivin and c-MYC in 24 cases of gastric cancer tissues and adjacent normal tissues was detected im-munohistochemically, the relationship between surviving, c-MYC and clinical pathological parameters was analyzed. Re-sult The positive rate of survivin and c-MYC in gastric cancer was higher than that in adjacent normal tissues (P<0.01). The positive expression of survivin was significantly higher in poorly differentiated cancer than highly and moderately differentiated cancer (P<0.01), and was also higher in stageⅢ～Ⅳdisease than that in stage I～Ⅱdisease, besides, higher expression was associated with lymph node metastasis (P<0.05). As for the positive expression of c-MYC, it was higher in patients with poorly differentiated cancer, stageⅢ～Ⅳdisease, and in those with lymph node metastasis, as compared with patients with highly or moderately differentiated cancer, stage I～Ⅱdisease, without lymph node metastasis (P<0.05). In gastric cancer tissues, the expression of survivin was positively correlated with the expression of c-MYC, differentia-tion degree and TNM stage (r=0.856, 0.973, 0.630, P<0.01), as well as the presence of lymph node metastasis (r=0.472, P<0.05);in gastric cancer tissues, c-MYC was positively correlated with differentiation degree, TNM stage, and lymph node metastasis (r=0.714, 0.734, 0.590, P<0.01). Conclusion Surivin and c-MYC are highly expressed in gastric cancer, promoting the occurrence and development of gastric cancer, and may be a marker for the diagnosis of gastric cancer.%目的 探讨胃癌组织中survivin和c-MYC的表达及意义.方法 采用免疫组化法检测24例胃癌组织及其癌旁正常组织中survivin和c-MYC的阳性表达情况,分析其与临床特征的关系.结果 胃癌组织中survivin和c-MYC的阳性表达率明显高于癌旁正常组织(P﹤0.01).低分化癌组织中survivin的阳性表达明显高于高、中分化癌(P﹤0.01),Ⅲ～Ⅳ期癌组织中survivin的阳性表达高于Ⅰ～Ⅱ期(P﹤0.05),有淋巴结转移的癌组织中sur-vivin的阳性表达高于无淋巴结转移者(P﹤0.05).低分化癌组织中c-MYC的阳性表达明显高于高、中分化癌,Ⅲ～Ⅳ期癌组织中c-MYC的阳性表达明显高于Ⅰ～Ⅱ期,有淋巴结转移的癌组织中c-MYC的阳性表达明显高于无淋巴结转移者,差异均有统计学意义(P﹤0.01).胃癌组织中survivin与c-MYC、分化程度、TNM分期呈正相关(r=0.856、0.973、0.630,P﹤0.01),与淋巴结转移亦呈正相关(r=0.472,P﹤0.05);胃癌组织中c-MYC与分化程度、TNM分期、淋巴结转移呈正相关(r=0.714、0.734、0.590,P﹤0.01).结论 在胃癌组织中survivin和c-MYC表达较高,对胃癌的发生、发展起到促进作用,可成为胃癌诊断的判断指标.