Analysis of influencing factors on the method for determining boron concentration and dose through dual prompt gamma detection

摘要

A method based on the cross-sectional relationship between^(10)B(n,α)^(7)Li and^(1)H(n,γ)^(2)H was proposed to detect and reconstruct the three-dimensional boron concentration/dose distribution in vivo during boron neutron capture therapy(BNCT).Factors such as the neutron energy,fluence rate,and degree of non-uniform distribution of the boron concentration in a voxel may affect the results of this method.A theoretical analysis of the accuracy of the method using a Monte Carlo simulation shows that the determining error is generally less than 1%under different tumor locations and neutron source configurations.When the voxel size is larger than 0.4 cm,the determining error might be higher for a non-uniformly distributed boron concentration in the voxel because of the changes in the neutron energy and fluence rate.In conclusion,the proposed method enables an accurate threedimensional boron determination in vivo during BNCT.