Study of proton radiolysis of solid uracil film

摘要

In order to understand the molecules mechanism of ion irradiation,which has been widely used in many fields such as cancer therapy,uracil,one of the bases of nucleic acid.was chosen in the low energy ion radiolysis research.The solid uracil films with mass thickness of 0.314mg/cm^2 were irradiated by 200keV H^+ ions .The experimental results show that 200keV H^+ ions are effective in decomposition of uracil molecules.One of the decomposition products,5,6-dihydro-uracil,was separated by high performance liquid chromatograph (HPLC) and detected using an UV-light detector.Its yield increases first but then decreases as the ion dose increasing.In addition,the mechanism of uracil decomposition and 5,6-dihydro-uracil formation was also disucssed.