While multiple sclerosis (MS) is more common among Caucasian populations, its prevalence is increasingly noted in ethnic groups that had previously been considered to have a low frequency of the disease. Epidemiologic studies indicate a considerable augmentation of MS presence in areas such the Middle East[1] and Latin American countries[2]. Along with the general clinical effects of this complex neurological disorder is the impact exerted by some of its comorbid neuropsychiatric manifestations particularly depression, described as affecting three times higher MS patients than the general population[3]. Literature and general perceptions had suggested clinical depression, although chronic in most MS cases, was unrelated to disability progression or disease course[4,5].
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