Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A

摘要

Human brains represent only 2%of body mass,but their high relative metabolic activity accounts for~20%of total body adenosine triphosphate(ATP)consumption.ATP generated by neuronal mitochondria fuels nerve signaling and homeostatic repair.In the peripheral nervous system,which has greater capacity for regeneration after physical,toxic or genetic injury than the central nervous system,ATP also powers actin polymerization/depolymerization for growth cone formation and axon extension.Mitochondrial ATP generation is therefore a central component of neuronal functioning in the central and peripheral nervous systems.