Previous studies have demonstrated that advanced Alzheimer's disease (AD) patients have deficiency of eye movements. However, there have been no reports on eye movement in the early stages of AD. The aim of this study was to evaluate pursuit ocular movements (POM) provided by a vision-based non-intrusive eye tracker in patients with early AD. POM values were significantly lower in AD patients than in normal controls (P < 0.01). In AD patients, POM values were not closely correlated with the Mini-Mental State Examination scores (P = 0.3). There was no significant difference in POM values among patients treated with or without anticholinesterase therapy. We used a vision-based method, for non-intrusive eye tracking, which can be proposed as a possible tool for supporting the diagnosis of early AD.
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