Endovascular middle cerebral arterial occlusion in a nonhuman primate model of chronic stroke

摘要

No study has reported the safety,effectiveness,and consistency of endovascular middle cerebral artery occlusion in a chronic cerebral ischemia model.Nor have studies verified the safest and most effective segment,or branch,in the embolic middle cerebral artery.In this experiment,cerebral infarction models were established at M1,and on the upper and lower trunks on the contralateral side of the handedness of rhesus monkeys by using endovascular intervention.The results confirmed a high animal survival rate in stroke models of middle cerebral artery upper trunk occlusion.There was pronounced paralysis at the acute phase,long-term upper extremity dysfunction at the chronic phase,and the models showed good repeatability and consistency.Thus,this study describes a safe and effective model of chronic stroke.