The neuroprotective and regenerative potential of parkin and GDNF/Ret signaling in the midbrain dopaminergic system

摘要

Parkinson’s disease(PD)is the second most common neurodegenerative disease after Alzheimer’s disease.The etiology of PD is still not completely understood,but the degeneration of dopaminergic(DA)neurons in the substantia nigra pars compacta(SNpc),loss of DA innervation of the striatum,and protein aggregates in the form of Lewy bodies and neurites