Phage display:development of nanocarriers for targeted drug delivery to the brain

摘要

The blood brain barrier represents a formidable obstacle for the transport of most systemati-cally administered neurodiagnostics and neurotherapeutics to the brain. Phage display is a high throughput screening strategy that can be used for the construction of nanomaterial peptide libraries. These libraries can be screened for ifnding brain targeting peptide ligands. Surface func-tionalization of a variety of nanocarriers with these brain homing peptides is a sophisticated way to develop nanobiotechnology-based drug delivery platforms that are able to cross the blood brain barrier. These efifcient drug delivery systems raise our hopes for the diagnosis and treatment of various brain disorders in the future.