3D printed nerve guidance channels: computer-aided control of geometry, physical cues, biological supplements and gradients

摘要

Nerve guidance channels for peripheral nerve injury:Over the past decade,nerve guidance channels(NGCs)have emerged as a promising technology for regenerating gap injuries in peripheral nerves.Nerve gap injuries resulting from neurodegeneration and trauma,such as car accidents and battlefield wounds,affect hundreds of thousands of people annually.Motivated by suboptimal results obtained with the current gold standard of autologous grafting(i.e.,autografts),various commercially available NGCs composed of synthetic and biomaterials are now