Repurposing cancer drugs to treat neurological diseases–Src inhibitors as examples

摘要

Aberrant cell cycle diseases:The cell cycle is an irreversible,ordered set of events that normally leads to cellular division,consisting of quiescent state(G0),the first gap phase(G1),DNA synthetic phase(S),the second gap phase(G2)and mitosis phase(M).After the cell has split into its two daughter cells,the new cells enter either G1 or G0.Aberrant cell cycle is one of the hallmarks of many tumor cells in cancers,and also observed in postmortem and/or animal studies