The Anaphase-Promoting Complex/Cyclosome in Control of Plant Development

摘要

Temporal controlled degradation of key cell division proteins ensures a correct onset of the different cell cycle phases and exit from the cell division program.In light of the cell cycle,the Anaphase-Promoting Complex/Cyclosome (APC/C) is an important conserved multi-subunit ubiquitin ligase,marking targets for degradation by the 26S proteasome.However,whereas the APC/C has been studied extensively in yeast and mammals,only in the last decade has the plant APC/C started to unveil its secrets.Research results have shown the importance of the APC/C core complex and its activators during gametogenesis,growth,hormone signaling,symbiotic interactions,and endoreduplication onset.In addition,recently,the first plant APC/C inhibitors have been reported,allowing a fine-tuning of APC/C activity during the cell cycle.Together with the identification of the first APC/C targets,a picture emerges of APC/C activity being essential for many different developmental processes.