Functional Partition of Cpn60α and Cpn60β Subunits in Substrate Recognition and Cooperation with Co-chaperonins

摘要

Dear editor, A multitude of proteins in cells are assisted in their folding by cylindrical double-ring chaperonin complexes.Group I chaperonin,such as prokaryotic GroEL,mitochondrial Hsp60,and chloroplastic Cpn60,consists of 14 subunits that are organized into two rings stacked back to back,with each ring possessing an internal central cavity to allow the protein to fold inside(Hartl et al.,2011).