Objective To survey the prevalence of depression and related factors in maintenance hemodialysis patients to provide basis for treatment strategy and the quality improving of life. Methods 67 cases of hemodialysis patients were studied by cross sectional and investigated with hamilton depres-sion scale. They were divided into depression group and non depression group, at the same time the basic data and laboratory data was collected. Results Depression prevalence in maintenance hemodial-ysis patients was 61%. Single rate in depression patients, serum C-reactive protein levels were signifi-cantly higher than non-depressed patients. While the hemoglobin, serum albumin levels were signifi-cantly lower, further found that the patient’s age, gender, dialysis time, culture degree, and dialysis suf-ficiency in the two groups had no significant difference. Conclusion Prevalence of depression in main-tenance hemodialysis patients was high. It were associated with marital status, renal anemia, chronic in-flammation and nutrition state. The marital status, hemoglobin level may be important factors.%目的：调查维持性血液透析患者抑郁患病发生情况并分析其影响因素，为制定治疗策略，提高生存质量提供依据。方法采用横断面研究，应用汉密尔顿抑郁量表调查规律性血液透析患者67例，将患者分为抑郁组及非抑郁组，同时收集患者的基本资料及实验室数据。结果67例维持性血液透析患者中抑郁患病率为61%，抑郁患者中独身率，血清C反应蛋白水平明显高于非抑郁患者，而血红蛋白，血清白蛋白水平则明显偏低，进一步发现患者的年龄，性别，透析时间，文化程度，及透析充分性在两组之间无显著差异。结论维持性血液透析患者中抑郁患病率高，与婚姻状况，肾性贫血，慢性炎症及营养状态有关，其中婚姻状况，血红蛋白的水平可能是重要的相关因素。
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