Correlation of pelvic floor ultrasound parameter with extracellular matrix remodeling and apoptosis in patients with stress urinary incontinence

摘要

cqvip:Objective: To study the correlation of pelvic floor ultrasound parameter with extracellular matrix remodeling and apoptosis in patients with stress urinary incontinence. Methods:Patients with stress urinary incontinence who underwent surgical treatment in Tianmen First People's Hospital in Hubei Province between March 2015 and August 2017 were selected as the SUI group of the research and patients who underwent total hysterectomy due to benign uterine lesions in Tianmen First People's Hospital in Hubei Province over the same period were selected as the control group of the research. Pelvic floor ultrasonography was done before surgery to measure the bladder neck descent (BND), and pelvic floor tissue was collected after surgery to determine the contents of Col-I, Col-III, TGF-β1, MMP1, MMP9, TIMP1, E-cadherin, Bax, Bcl-2, Bcl-xL, Caspase-3 and HIF-1 . Results: The pelvic floor ultrasound parameter BND of SUI group was significantly higher than that of control group;Col-I, Col-III, TIMP1, E-cadherin, Bcl-2 and Bcl-xL contents in the pelvic floor tissue of SUI group were significantly lower than those of control group whereas TGF-β1, MMP1, MMP9, Bax, Caspase-3 and HIF-1 contents were significantly higher than those of control group;Col-I, Col-III, TIMP1, E-cadherin, Bcl-2 and Bcl-xL contents in the pelvic floor tissue of SUI group of patients with high BND were significantly lower than those of patients with low BND whereas TGF-β1, MMP1, MMP9, Bax, Caspase-3 and HIF-1 contents were significantly higher than those of patients with low BND. Conclusion: The change of pelvic floor ultrasound parameter BND in patients with stress urinary incontinence is closely related to the extracellular matrix remodeling and apoptosis in pelvic floor tissue.