Correlation between NF-κB, TGF-β1 in patients with left ventricular diastolic failure and left ventricular remodeling

摘要

Objective:To investigate the expression changes of nuclear factor-kappa B (NF-κB) and transforming growth factor-beta (TGF-β1) in patients with left ventricular failure and its correlation with left ventricular remodeling and clinical pathological significance. Methods:A total of 150 patients diagnosed with diastolic heart failure (DHF) were recruited as the DHF group and 30 normal subjects were selected as control group. The peripheral blood samples of both groups were respectively collected. A double-antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to detect the expression levels of peripheral blood NF-κB and serum TGF-β1. Results:Compared with the control group, the levels of peripheral blood TGF-β1 and NF-κB were significantly higher in the DHF group (P<0.05), and the levels of TGF-β1 and NF-κB rose correspondingly when cardiac function got worsen (P<0.05), indicating that the cardiac function was getting worse. The levels of TGF-β1 and NF-κB were positively correlated with left ventricular mass index (LVMI) and mean wall stress (MWS) (r=0.567, P<0.01). Conclusions:The expression levels of TGF-β1 and NF-κB considered as DHF serum markers in peripheral blood are obviously changing, which plays an important role in promoting the occurrence and development of ventricular remodeling.