Effect of exenatide combined with metformin therapy on insulin resistance,liver function and inflammatory response in patients with type 2 diabetes mellitus combined with NAFLD

摘要

Objective: To study the effect of exenatide combined with metformin therapy on insulin resistance, liver function and inflammatory response in patients with type 2 diabetes mellitus combined with NAFLD. Methods: A total of 98 patients with type 2 diabetes mellitus combined with NAFLD who were treated in the hospital between February 2015 and January 2017 were divided into control group and observation group by random number table, each with 49 cases. Control group received metformin therapy, and observation group received exenatide combined with metformin therapy. Serum levels of insulin resistance indexes, liver function indexes and inflammatory factors of two groups of patients were detected before treatment and after 12 weeks of treatment. Results: Before treatment, serum levels of insulin resistance indexes, liver function indexes and inflammatory factors were not significantly different between the two groups of patients;after 12 weeks of treatment, serum INS and HOMA-IR levels as well as AST, ALT, GGT, ALP, hs-CRP, IL-1β and IL-6 contents of observation group were lower than those of control group. Conclusion: Exenatide combined with metformin therapy can effectively reduce insulin resistance, reduce liver function injury and inhibit systemic inflammatory response in patients with type 2 diabetes mellitus combined with NAFLD.