Objective: To study the protective effect of Peroxiredoxin 6 (PRDX6) treatment on the rat model with corneal injury caused by ultraviolet ray. Methods: SD male rats were selected as experimental animals and randomly divided into control group, model group and PRDX6 group, corneal injury models were established by UV irradiation, and they received PRDX6 intervention. The contents of oxidative stress molecules, apoptosis molecules and MMPs/TIMPs in corneal tissues were detected on the 12 d after intervention. Results: MDA, AOPP, Fas, FasL, Bax, Caspase-3, MMP2 and MMP9 contents in corneal tissue of model group were significantly higher than those of control group while T-AOC, SOD, GSH-Px, Bcl-2, Survivin, XIAP, TIMP1 and TIMP2 contents were significantly lower than those of control group;MDA, AOPP, Fas, FasL, Bax, Caspase-3, MMP2 and MMP9 contents in corneal tissue of PRDX6 group were significantly lower than those of model group while T-AOC, SOD, GSH-Px, Bcl-2, Survivin, XIAP, TIMP1 and TIMP2 contents were significantly higher than those of model group. Conclusion: PRDX6 has inhibitory effect on the oxidative stress and apoptosis in corneal injury process caused by ultraviolet ray.
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