心力衰竭发病机制的研究进展

摘要

心力衰竭(CHF)是儿科常见急症,常危及生命.目前研究认为系统炎性反应是CHF重要的病理生理机制之一,各种炎性因子的过度表达,可以影响心肌细胞的收缩性,并诱导心肌细胞的纤维化.各种炎性介质、细胞因子的大量产生可进一步导致心肌细胞凋亡、心肌重塑.利钠肽类激素的激活是CHF的代偿因素,所以CHF是多因素相互作用的过程.%Congestive heart failure( CHF ) is a common pediatric emergency, often life-threatening.Accumulating studies have proved that systemic inflammation is one of the important pathophysiologic mechanisms of CHF.Overexpression of various inflammatory cytokines can affect the contraction of myocardial cells and induce fibrosis of myocardial cells.All kinds of inflammatory mediators, cytokines may further lead to myocardial apoptosis and cardiac remodeling.However, natriuretic peptide hormone activation is a compensatory factor in CHF, therefore, CHF is a multifactorial interaction.