Primary gallbladder carcinoma is the most cormmon malignant biliary tumor, and surgery is still the most recognized and effective treatment. However,because of the high degree of malignancy, the lack of specific clinical manifestations, early diagnosis is difficult , most patients are already in the middle late stage with liver invasion or distant metastasis when going to the doctor, and have lost the chance of radical resection resulting in a low survival rate and bad prognosis. In recent years , the rapid development of molecular hiology techniques have clarified the mechanism of tumor occurrence and development gradually providing new treatments. In particular, significant achievements have been made in the research of tumor angiogenesis and antiangiogenesis.%原发性胆囊癌是胆道系统最常见的恶性肿瘤,手术是目前公认的最有效的治疗方法.但因其恶性程度高,又缺乏特异性的临床表现,早期诊断困难,多数患者就诊时已属中晚期,伴发肝脏浸润或远处转移,失去了根治切除的机会,生存率低,预后差.近年来随着分子生物学技术的迅速发展,已从分子水平逐步阐明了肿瘤的发生、发展机制,也为肿瘤的治疗提供了一条新途径.特别在关于肿瘤新生血管调控及抗血管治疗等方面的研究,已取得了重要成果.
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