全脑缺血/再灌注致线粒体损伤的研究进展

摘要

能量代谢障碍是心跳呼吸骤停后脑损伤的主要病理生理改变,其损伤机制与心跳骤停后全脑缺血/再灌注导致的脑组织氧供和能量代谢紊乱有关.线粒体是产生三磷酸腺苷的主要场所,也是缺血/再灌注损伤的重要靶器官,它的损伤可能是导致脑细胞能量代谢障碍的关键.现就全脑缺血/再灌注后线粒体损伤变化的研究进展予以综述.%Energy metabolism failure is a main pathophysiological change of brain injury after cardiac arrest.Its damage mechanism is associated with brain tissue oxygen supply and energy metabolism disorder caused by complete cerebral ischemia-reperfusion after cardiac arrest.Mitochondria is the main site to produce adenosine triphosphate,as well as the targeted organ in ischemia-reperfusion, so its injury may be the key of causing cellular energy metabolism disturbance.The research progress of mitochondrial changes after global cerebral ischemia-reperfusion are reviewed here.