β抑制蛋白(即β-arrestin)1和β-arrestin 2是一类介导受体脱敏的重要可溶性蛋白质,对绝大部分与受体耦联G蛋白介导的信号转导具有重要调节作用.在G蛋白耦联受体(GPCRs)脱敏、内化、复敏、细胞增殖反应和基因转录中具有重要地位.β-arrestin能够通过GPCRs或其他一些信号转导途径影响肿瘤细胞生长、迁移、转移进程.现就β-arrestin在肿瘤的发生和转移过程中所起到的作用及目前的研究状况予以综述.%β-suppression protein ( β-arrestin ) 1 and 2 are a group of soluable proteins mediating receptor desensitization, which regulate receptor-coupled G protein mediated signaling.β-arrestins play an important role in the desensitization, interlocation, resensitization, cell proliferation and gene transcription of Gprotein coupled receptors ( GPCRs ).β-arrestins are implicated in the growth, migration, and metastasis of tumor cells through GPCRs or other signaling.This article reviews the effects of β-arrestins in the occurrences and metastases of tumors.
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