大部分肺部疾病的发生机制十分复杂,目前认为其病变的发生与发展是趋化因子、细胞因子和活性代谢产物等综合作用的结果.单核细胞趋化蛋白1(MCP-1)是一种分泌型单链蛋白质,为趋化因子家族成员之一.目前的研究已经表明,MCP-1在肺损伤、肺血栓、肺纤维化、慢性阻塞性肺疾病、肺部肿瘤、肺结核等肺部疾病中发挥重大作用.现就其特点、功能及与这些肺部疾病的关系予以综述.%The inechanisms of most pulmonary diseases are very complicated,and their occurrence and development were thought to be the results from joint effects of chemokines,cytokines,active metabolite. Monocyte chemoattractant protein-1( MCP-1 )is a secret017 single stranded protein, which is a member of C-C chemokine family. Recent studies have shown that MCP-1 plays a great role in some pulmonary diseases such asiactue lung injui7,pulmonai7 embolism,pulmonary fibrosis,chronic obstmctive pulmonai7 disease,lung cancel' and pulmonary tuberculosis and so on. Here is to make a review on its features, functions and correlation with the pulmonary diseases.
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