相丹峰NLK的信号转导和生物学效应的研究进展

摘要

NLK是一种进化保守的丝裂原活化蛋白激酶类似的激酶,属于丝氨酸/苏氨酸蛋白激酶.近年来大量研究表明,NLK的信号转导在低等动物和哺乳动物细胞中发挥着重要的生物学效应.NLK能够调控许多转录因子,如T细胞因子/淋巴细胞增强因子、c-Myb、转录激活因子3、Notch/Delta等,从而导致一系列的生物学效应.正是由于NLK本身具有对多种转录因子的调节功能,使其在细胞的增殖、分化和凋亡、肿瘤发生和免疫反应中都发挥重要的作用.%NLK (Nemo-eike kinase)is an evolutionary conservative kinase closely related to mitogen-actived protein kinases( MAPK )which belongs to serine/threonine protein kinase. In recant years, many of studies have shown that NLK signal transduction plays an important biological effects in lower class animal's cells and mammalian cells. NLK regulate and'control of many transcription factors, such as TCF/ LEF, c-Myb, STAT3 , Notch/Delta and so on,resulting in a series of biological effects. Owing to its regulatory Junctions of a variety of transcription factors,NLK plays vital roles in regulation of cell proliferation, differentiation,apoptosis,cancel- development and immune response.