肝内肿瘤干细胞与肝癌的相关研究进展

摘要

肝癌是一种恶性程度高的肿瘤,临床上缺乏有效的治疗方法.有确切的证据表明肿瘤干细胞(CSCs)不仅与肿瘤的启动有关,且与肿瘤的远处转移和术后复发相关.最近,肝内CSCs的研究引起了人们的广泛关注,作为一种肿瘤起始细胞,其广泛存在于肝癌患者肿瘤组织和外周循环中.肝脏CSCs的特性(如自我更新、无限增生和分化)与肝癌的复发和药物抵抗高度相关,这些都是肝癌治疗效果不佳的根本原因.现就CSCs的概念、特征、肝内CSCs的来源、自我更新能力的调控及基于CSCs靶向治疗肝癌的重要策略等进行综述.%Hepatocellular rarrinoma is a highly malignant tumor lark of effective rliniral treatments. The compelling evidence has suggested that cancel- stem cells( CSCs )are responsible not only for tumor initiation but also for the generation of distant metastasis and recurrence. Recently, CSCs in livej have attracted extensive attention as a tumor-initiating cell demonstrated in liver cancer tissues and peripheral circulation ol hepa-tocellulai- caicinoma patients. Moieovei, liver CSCs properties such as self -renewal, unlimited proliferation and differentiation are highly relevant to cancer recurrence and the drug resistance, which are attributed to the poor effects of HCC treatment. Here is to make a review on the concept, characteristies of liver CSCs, and summarize the origin,regulation of self-renewal of CSCs in liver and the strategy of CSCs-targeted therapy lor hepato-cellular caicinoma.