催乳素对系统性红斑狼疮的影响

摘要

Prolactin( PRL)is a kind oi pure proteohormone secreted by adenohypophysis eosinophilic granulocyte, which is composed oi 199 amino-arid residues and has an relation between modulation oi secretion and hypothalamus. It plays a main role in mammotrophic and lactogenic efferts,also in maintaining lactation. Evidence also supports an association between prolactin levels and the activity oi human autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, and Reiter's syndrome etc. . Here is to make a review on the roles oi prolactin in systemic lupus erythematosus,and its correlation with the activity oi the disease.%催乳素是腺垂体嗜酸粒细胞分泌的一种纯蛋白激素,由199个氨基酸残基所组成,分泌的调节与下丘脑有关.主要作用是发挥亲乳腺效应,刺激乳腺泌乳,并维持泌乳状态.研究显示,催乳素水平与人类一些自身免疫紊乱疾病的活跃性密切相关,这类疾病包括系统性红斑狼疮、类风湿关节炎、瑞特综合征等.现对催乳素在系统性红斑狼疮发病中的作用及与系统性红斑狼疮活跃性的关系进行综述.