肥胖是Barrett食管(BE)发生、发展的危险因素,然而肥胖是否是BE发生的独立危险因素还存在争论.有研究证明,腹型肥胖,尤其是内脏肥胖是BE发生的独立危险因素.肥胖作为BE发生的危险因素,其机制尚不明确.腹型肥胖导致胃内压力增加,胃酸反流入食管,导致食管长期暴露于酸性环境,发生食管炎进而发展为BE;肥胖者体内脂肪组织代谢增加,血浆中脂肪素、瘦素水平增加,脂联素水平降低,这些都可能与BE以及食管腺癌的发病有关.%It has been confirmed that obesity is a risk iartor ior Barrett's esophagus( BE ). However,it is still controversial whether obesity is an independent risk factors ior BE. Recent studies proved that abdominal obesity,especially visceral obesity is an independent risk iartor ior BE. The mechanism of obesity inducing BE is still unclear. The abdominal obesity causes the increased intragastric pressure resulting in gastric acid flowing into the esophagus, which leads to long-term esophageal acid exposure to develop BE ; obesity increases the body's metabolism oi adipose tissue as well as plasma adipokines and leptin levels and decreases adi-ponectin levels,all oi which might be involved in the pathogenesis oi BE and esophageal adenocarcinoma.
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