2型糖尿病患者血管内皮功能紊乱和尿微量白蛋白的关系

摘要

Objective To discuss the correlation between vascular endothelial function and microalbu-minuria in patients with type, 2 diabetes. Methods 128 patients with type, 2 diabetes were enrolled in the cross-sectional study. The clinical data, conducted laboratory tests, calculated urinary albumin excretion rate ( UAER )of these patients were collected. Meanwhile,the endothelial function were evaluated by brachial artery flow-mediated dilation( FMD ). Results FMD was associated with microalbuminuria( r = 0.315, P=0.003),HbAlc(r= -0. 284 ,P = 0. 014 )and body mass index( r = - 0. 210, P =0. 040 ). Multiple regression analysis showed that microalbuminuria and HbAlc were the independent determinants of FMD ( adjusted r2 = 0. 280 ,P ＜0. 01 ). Conclusion Microalbuminuria is the independent predictor oi FMD in patients with type 2 diabetes.%目的 探讨2型糖尿病患者血管内皮功能与尿微量白蛋白的关系.方法 收集128例2型糖尿病患者的一般临床资料,并对患者的生化指标和尿白蛋白排泄率(UAER)进行检测,采用血流介导的肱动脉扩张(FMD)法评估其血管内皮功能.结果 2型糖尿病患者的FMD与UAER(r=-0.315,P=0.003)、糖化血红蛋白(r=-0.284,P=0.014)、体质量指数(BMI)(r=-0.210,P=0.040)呈负相关关系,多元回归分析表明UAER和HbA1c是内皮功能的独立影响因素(调整的r2=0.280,P＜0.01).结论 尿微量白蛋白是2型糖尿病患者血管内皮功能的独立预测因素.