干扰素λ的表达机制

摘要

Interferon-X( IFN-X )are antiviral cytokines with type I IFN-like biological functions. While IFN-α expression is activated by multiple IFN regulatory fartors( IRFs )-binding cis-promoter elements, and IFN-β is induced by coordinated action of a multifactor enhanceosome,IFN- λ. are induced through independent actions of IRFs and nuclear factor-KB( NF-kB ). The mechanisms governing IFN-λ. expression plays an important part in dictating the biological fuction oi the cytokine. Here is to make a review on the literature on IFN-λ expression and propose that important differences may exist between the mechanisms governing expression oi different IFNs.%干扰素λ(IFN-λ)是具有抗病毒活性的细胞因子,含有Ⅰ型IFN的生物学功能.IFN-α的表达由多个IFN调节因子(IRFs)顺式原件激活,IFN-β通过上游的增强子区域的协调活动来诱导产生,IFN-λ可通过IFN调节因子(IRFs)和核因子κB(NF-κB)单独诱导.这种调节IFN-λ表达的机制在决定该细胞因子的生物学功能方面起了重要作用.不同类型IFN的表达机制可能存在很大的差异,在此对IFN-λ的表达机制的相关文献予以综述.