嗜酸性膀胱炎(EC)是一种罕见的临床病理学征象,其特征是以嗜酸粒细胞浸润为主的膀胱透壁炎症.尽管EC可能与一些致病因素有关,如变态反应、寄生虫感染、药物、膀胱损伤、膀胱肿瘤等,但其致病机制仍然不太清楚.最常见的临床表现包括尿频、血尿、排尿困难和耻骨上疼痛.膀胱镜检查和病理活检是诊断的金标准.另外,支持诊断的实验室证据包括蛋白尿、镜下血尿和外周血嗜酸粒细胞增多症.目前的治疗方案包括经尿道切除膀胱病变及药物治疗,如非甾体类抗炎药或皮质类固醇.在上述治疗下病变有复发的趋势,故长期随访是有必要的.%Eosinophilic cystitis( EC )is a rare clinicopathological condition characterized by transmural inflammation oi the bladder predominantly with eosinophils. The cause oi EC remains uncleai, although it has been associated with various etiological factors,such as allergy',paiasitic infections and chemotherapeu-tic agents,bladder trauma,bladder tumor etc. . The most common symptom complex consists oi frequent urination, heamaturia,dysuria and supiapubic pain. Cystoscopy and biopsy are the gold standard for diagnosis. Additional laboratory evidence supporting the diagnosis includes proteinuria, microscopic heamatuiia and peripheral eosinophilia. Current treatment modalities include transurethral resection oi the bladder lesion a-long with non-speciiic medical therapy, such as non-steioidal anti-inflammatory agents or steroids. Because the lesion tends to recur in spite oi the above therapy,long-term fallow-up is necessary.
展开▼
